Using Opioid Receptors to Expand the Chemogenetic and Optogenetic Toolbox
نویسندگان
چکیده
In this issue of Neuron, innovative new modifications to opioid receptors are used to expand the tools available to modulate neuronal activity. Vardy et al. (2015) describe a new "DREADD" chemogenetic tool based on the inhibitory κ opioid receptor (KORD) that can be used in conjunction with already-available DREADDs. Siuda et al. (2015) report the development of "opto-MOR," a light-activatable μ opioid receptor (MOR) chimera that can be used to better understand the complexities of MOR signaling.
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ورودعنوان ژورنال:
- Neuron
دوره 86 شماره
صفحات -
تاریخ انتشار 2015